Katherine Samaras is a senior staff specialist in endocrinology and metabolism at St Vincent's Hospital in Sydney and group leader in Clinical Diabetes and Obesity at the Garvan Institute of Medical Research. Katherine's everyday clinical medicine and research revolves around diabetes and obesity. In her clinical role, she actively engages obese patients with major illness in weight reduction, as a core means of achieving better health. Katherine's research is helping to unravel the mysteries of fat tissue and how it affects our health, particularly how inflammation promotes different diseases, including diabetes, heart failure, cognition and dementia. A major project is focused on reversing diabetes through diet change and weight loss.